生物活性

• 描述Riluzole is a glutamate antagonist used as an anticonvulsant and to prolong the survival of patients with amyotrophic lateral sclerosis.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03359538	Amyotrophic Lateral Sclerosis	Phase 2	Recruiting	September 19, 2019	Italy ... more >> Centro Sla, Irccs A.O.U. S.Martino Ist, Genova Not yet recruiting Genova, Italy Contact: Claudia Caponnetto, MD          Centro Clinico Nemo, Fondazione Serena Onlus, Milano Not yet recruiting Milano, Italy Contact: Christian Lunetta, MD          Centro Sla, Irccs Fondazione Salvatore Maugeri, Milano Not yet recruiting Milano, Italy Contact: Kalliopi Marinou, MD          Centro Sla, Irccs Istituto Carlo Besta, Milano Not yet recruiting Milano, Italy Contact: Eleonora Dalla Bella, MD          Centro Sla, Ospedale Civile S. Agostino Estense, A.O.U. Modena Recruiting Modena, Italy, 41126 Contact: Jessica Mandrioli, MD    +390593961722       Centro Sla, A.O.U. Maggiore Della Carita', Novara Not yet recruiting Novara, Italy Contact: Letizia Mazzini, MD          Centro Sla, Universita' Di Padova Not yet recruiting Padova, Italy Contact: Gianni Sorarù, MD          Centro Sla, Universita' Di Torino Not yet recruiting Torino, Italy Contact: Adriano Chiò, Prof. Collapse <<
  NCT01378676	Amyotrophic Lateral Sclerosis	Phase 2	Completed	-	United States, California ... more >> California Pacific Medical Center San Francisco, California, United States, 94115 United States, Florida Mayo Florida Jacksonville, Florida, United States, 32224 United States, Kansas University of Kansas Kansas City, Kansas, United States, 06053 United States, Maryland Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 United States, New York Columbia University Medical Center New York, New York, United States, 10032 SUNY Upstate Medical Center Syracuse, New York, United States, 13210 United States, North Carolina Carolinas Neuromuscular ALS-MND Center Charlotte, North Carolina, United States, 28207 United States, Pennsylvania Penn State Hershey Medical Center Hershey, Pennsylvania, United States, 17033 Drexel University College of Medicine Philadelphia, Pennsylvania, United States, 19107 Collapse <<
  NCT00560287	Amyotrophic Lateral Sclerosis ... more >> Chronic Respiratory Failure Collapse <<	Phase 4	Unknown	August 2010	Italy ... more >> Fondazione S.Maugeri Recruiting Pavia, Italy, 27100 Contact: Stefano Nava, md    o3825921    snava@fsm.it    Contact: Stefano Nava, md    03825921    snava@fsm.it    Respiratory Unit FSM Not yet recruiting Pavia, Italy, 27100 Contact: Stefano Nava, md    0382 592 ext 806    snava@fsm.it    Contact: Francesco Fanfulla, MD    0382 592 ext 815    ffanfulla@fsm.it    Principal Investigator: Stefano Nava, MD Collapse <<

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• 参考文献

• [1] Romano S, Coarelli G, et al. Riluzole in patients with hereditary cerebellar ataxia: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2015 Oct;14(10):985-91.

  [2] Nagoshi N, Nakashima H, et al. Riluzole as a neuroprotective drug for spinal cord injury: from bench to bedside. Molecules. 2015 Apr 29;20(5):7775-89.